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Stem Cells International - Volume 2016 2016, Article ID 2958210, 9 pages -

Review Article

School of Biotechnology, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand

School of Anatomy, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand

Received 11 December 2015; Accepted 14 March 2016

Academic Editor: Jason Meyer

Copyright © 2016 Piya Prajumwongs et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Although the mechanism of neurogenesis has been well documented in other organisms, there might be fundamental differences between human and those species referring to species-specific context. Based on principles learned from other systems, it is found that the signaling pathways required for neural induction and specification of human embryonic stem cells hESCs recapitulated those in the early embryo development in vivo at certain degree. This underscores the usefulness of hESCs in understanding early human neural development and reinforces the need to integrate the principles of developmental biology and hESC biology for an efficient neural differentiation.





Autor: Piya Prajumwongs, Oratai Weeranantanapan, Thiranut Jaroonwitchawan, and Parinya Noisa

Fuente: https://www.hindawi.com/



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