BDKRB2 9-−9 Polymorphism Is Associated with Higher Risk for Diabetes Mellitus in the Brazilian General PopulationReportar como inadecuado

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Experimental Diabetes ResearchVolume 2012 2012, Article ID 480251, 4 pages

Research Article

Laboratory of Genetics and Molecular Cardiology, Heart Institute InCor, University of Sao Paulo Medical School, Avenida Dr. Enéas de Carvalho Aguiar, 44 Cerqueira César, 05403-000 São Paulo, SP, Brazil

Department of Medicine, Ouro Preto Federal University, Ouro Preto, MG, Brazil

Department of Physiology, Espirito Santo Federal University, Vitória, ES, Brazil

Received 3 October 2012; Accepted 1 November 2012

Academic Editor: Aristidis Veves

Copyright © 2012 Rafael de Oliveira Alvim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Some mechanisms have been proposed to explain the role of bradykinin on glucose homeostasis and some studies reported that the BDKRB2 +9-−9 polymorphism was associated to the transcriptional activity of the receptor. In this scenario, the main aim of this study was to evaluate the association of the BDKRB2 +9-−9 polymorphism with diabetes mellitus risk in the Brazilian general population. This study included 1,032 subjects of the general urban population. Anthropometrical, blood pressure, biochemical, and genotype analyses for the BDKRB2 +9-−9 bp insertion-deletion polymorphism were performed. Individuals carrying +9-+9 or +9-−9 genotypes had higher glucose values 84.5 mg-dL versus 80.6 mg-dL, resp. and higher frequency of diabetes mellitus 7.6% versus 3.6%, resp. compared to individuals carrying −9-−9, adjusting for age and gender. In addition, higher diabetes mellitus risk was associated to presence of the +9-+9 or +9-−9 genotypes OR = 1.91; 95% CI = 1.09–4.19; . Our data suggest that the BDKRB2 +9-9 polymorphism may act as a genetic modulator of glucose homeostasis. It was previously associated to insulin sensitivity, glucose uptake, and insulin secretion, and, in this study, data suggest that the polymorphism may increase susceptibility to chronic metabolic conditions such as diabetes in the Brazilian population.

Autor: Rafael de Oliveira Alvim, Paulo C. J. L. Santos, Raimundo M. Nascimento, George L. L. M. Coelho, José G. Mill, José E. Krie



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