Expression Levels of Activated Leukocyte Cell Adhesion Molecule ALCAM-CD166 in Primary Breast Carcinoma and Distant Breast Cancer MetastasesReportar como inadecuado




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Disease Markers - Volume 28 2010, Issue 2, Pages 71-78



Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany

Institute for Pathology, University Hospital of Basel, Schönbeinstrasse 40, 4031 Basel, Switzerland

Department of Statistics and Epidemiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany

Received 25 March 2010; Accepted 25 March 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction: Activated Leukocyte Cell Adhesion Molecule ALCAM-CD166 gained increasing attention regarding tumorprogression and metastatic spread in breast cancer. The aim of this study was to examine ALCAM expression levels in primary breast cancer and distant metastases of the same patient within 29 autopsy cases to better understand the underlying mechanisms of metastases and the role of adhesion molecules in this process.

Material and Methods: Paraffin-embedded tissue of the primary and distant metastases N = 84 were collected and ALCAM immunohistochemistry was performed.

Results: The primary tumor and all metastases showed a statistically normally distributed ALCAM expression. ALCAM expression level average differs between immunoreactive score IRS mean 4.16 lung-5.00 adrenal gland. Of the metastatic ALCAM expression levels we obtained an intra-class correlation ICC of 80.9%, indicating a strong cluster effect of measurements in the same patient. ALCAM expression scores in metastatic sites and in the primary analyzed by hierarchical regression analysis showed that ALCAM expression in the primary is prognostic for ALCAM expression in all different sites of metastases slope = 0.773, p < 0.001, r

= 0.504.

Conclusion: ALCAM expression in the primary is positively correlated to ALCAM expression in metastases within one single patient. This could show a tumorbiological context of ALCAM for the development of metastases in breast cancer.





Autor: M. Ihnen, N. Köhler, J. F. Kersten, K. Milde-Langosch, K. Beck, S. Höller, V. Müller, I. Witzel, F. Jänicke, and E. Kilic

Fuente: https://www.hindawi.com/



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