Pneumatic tube system transport does not alter platelet function in optical and whole blood aggregometry, prothrombin time, activated partial thromboplastin time, platelet count and fibrinogen in patients on anti-platelet drug theReportar como inadecuado




Pneumatic tube system transport does not alter platelet function in optical and whole blood aggregometry, prothrombin time, activated partial thromboplastin time, platelet count and fibrinogen in patients on anti-platelet drug the - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Biochemia medica : Biochemia medica, Vol.27 No.1 February 2017. -

Introduction: The aim of this study was to assess pneumatic tube system PTS alteration on platelet function by the light transmission aggregometry LTA and whole blood aggregometry WBA method, and on the results of platelet count, prothrombin time PT, activated partial thromboplastin time APTT, and fibrinogen.

Materials and methods: Venous blood was collected into six 4.5 mL VACUETTE® 9NC coagulation sodium citrate 3.8% tubes Greiner Bio-One International GmbH, Kremsmünster, Austria from 49 intensive care unit ICU patients on dual anti-platelet therapy and immediately hand carried to the central laboratory. Blood samples were divided into 2 Groups: Group 1 samples N = 49 underwent PTS 4 m-s transport from the central laboratory to the distant laboratory and back to the central laboratory, whereas Group 2 samples N = 49 were excluded from PTS forces. In both groups, LTA and WBA stimulated with collagen, adenosine-5’-diphosphate ADP, arachidonic acid AA and thrombin-receptor-activated-peptide 6 TRAP-6 as well as platelet count, PT, APTT, and fibrinogen were performed.

Results: No statistically significant differences were observed between blood samples with Group 1 and without Group 2 PTS transport P values from 0.064 – 0.968. The AA-induced LTA bias: 68.57% exceeded the bias acceptance limit of ? 25%.

Conclusions: Blood sample transportation with computer controlled PTS in our hospital had no statistically significant effects on platelet aggregation determined in patients with anti-platelet therapy. Although AA induced LTA showed a significant bias, the diagnostic accuracy was not influenced.

platelets; platelet aggregation; platelet function tests; clinical laboratory services; preanalytical phase



Autor: Dietmar Enko - ; Institute of Clinical Chemistry and Laboratory Medicine, General Hospital Steyr, Steyr, Austria Harald Mangge -

Fuente: http://hrcak.srce.hr/



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