Fabrication of Nanohydroxyapatite-Polycaprolactone Composite Microfibers Using Electrospinning Technique for Tissue Engineering ApplicationsReportar como inadecuado




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Journal of Nanomaterials - Volume 2014 2014, Article ID 209049, 7 pages -

Research Article

Faculty of Biosciences and Medical Engineering FBME, Universiti Teknologi Malaysia UTM, Johor Bahru, 81310 Skudai, Johor, Malaysia

Miniaturized Medical Devices Program, Institute of Microelectronics, Agency for Science, Technology and Research A*STAR, Singapore 117685

Received 19 March 2014; Revised 5 June 2014; Accepted 16 June 2014; Published 25 June 2014

Academic Editor: Zhongkui Hong

Copyright © 2014 Mohd Izzat Hassan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tissue engineering fibrous scaffolds serve as three-dimensional 3D environmental framework by mimicking the extracellular matrix ECM for cells to grow. Biodegradable polycaprolactone PCL microfibers were fabricated to mimic the ECM as a scaffold with 7.5% w-v and 12.5% w-v concentrations. Lower PCL concentration of 7.5% w-v resulted in microfibers with bead defects. The average diameter of fibers increased at higher voltage and the distance of tip to collector. Further investigation was performed by the incorporation of nanosized hydroxyapatite nHA into microfibers. The incorporation of 10% w-w nHA with 7.5% w-v PCL solution produced submicron sized beadless fibers. The microfibrous scaffolds were evaluated using various techniques. Biodegradable PCL and nHA-PCL could be promising for tissue engineering scaffold application.





Autor: Mohd Izzat Hassan, Tao Sun, and Naznin Sultana

Fuente: https://www.hindawi.com/



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