Effect of Film-Forming Polymers on Release of Naftifine Hydrochloride from Nail LacquersReportar como inadecuado




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International Journal of Polymer Science - Volume 2017 2017, Article ID 1476270, 7 pages - https:-doi.org-10.1155-2017-1476270

Research ArticleDepartment of Clinical Pharmacy, Lithuanian University of Health Sciences, Sukilėlių Pr. 13, 50161 Kaunas, Lithuania

Correspondence should be addressed to Indrė Šveikauskaitė

Received 4 November 2016; Revised 11 January 2017; Accepted 23 January 2017; Published 16 February 2017

Academic Editor: Jaume Garcia-Amorós

Copyright © 2017 Indrė Šveikauskaitė and Vitalis Briedis. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The successful topical therapy of onychomycosis depends on effective drug release and penetration into nail, which can be achieved by using an adequately developed delivery system. This study evaluated and compared effect of film-forming polymers Eudragit RL100, Eudragit RS100, and ethyl cellulose on naftifine hydrochloride release from experimental nail lacquer formulations. Quality of formulations was evaluated by determining drying time and water resistance. Interactions between active pharmaceutical ingredient and excipients were investigated using microcalorimetry and FT-IR. Optimization of nail lacquer formulations was performed by naftifine hydrochloride release testing. Release of naftifine hydrochloride increased with increasing concentration of Eudragit RL100. Plasticizer triacetin affected the release of naftifine hydrochloride, when Eudragit RS100 polymer was used. Ethyl cellulose polymer was determined to be not applicable for naftifine hydrochloride nail lacquer formulations. Two compositions of nail lacquers were optimized and could be used in further development of transungual delivery systems.





Autor: Indrė Šveikauskaitė and Vitalis Briedis

Fuente: https://www.hindawi.com/



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