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Biochemistry Research InternationalVolume 2012 2012, Article ID 105203, 9 pages

Review Article

Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

Wellcome Trust-Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK

Received 10 January 2012; Revised 24 February 2012; Accepted 24 February 2012

Academic Editor: Malgorzata Kloc

Copyright © 2012 Magdalena J. Koziol and John B. Gurdon. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The translationally controlled tumor protein TCTP is highly conserved among animal species. It is widely expressed in many different tissues. It is involved in regulating many fundamental processes, such as cell proliferation and growth, apoptosis, pluripotency, and the cell cycle. Hence, it is not surprising that it is essential for normal development and, if misregulated, can lead to cancer. Provided herein is an overview of the diverse functions of TCTP, with a focus on development. Furthermore, we discuss possible ways by which TCTP misregulation or mutation could result in cancer.

Author: Magdalena J. Koziol and John B. Gurdon



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