Antioxidant and Antiplasmodial Activities of Bergenin and 11-O-Galloylbergenin Isolated from Mallotus philippensisReportar como inadecuado

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Oxidative Medicine and Cellular Longevity - Volume 2016 2016, Article ID 1051925, 6 pages -

Research Article

Department of Chemistry, Islamia College University, Peshawar 25120, Pakistan

Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan

Departamento de Química, Universidade Federal de Santa Catarina, 88040-900 Florianopolis, SC, Brazil

Received 23 October 2015; Revised 15 January 2016; Accepted 18 January 2016

Academic Editor: Denis Delic

Copyright © 2016 Hamayun Khan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Two important biologically active compounds were isolated from Mallotus philippensis. The isolated compounds were characterized using spectroanalytical techniques and found to be bergenin 1 and 11-O-galloylbergenin 2. The in vitro antioxidant and antiplasmodial activities of the isolated compounds were determined. For the antioxidant potential, three standard analytical protocols, namely, DPPH radical scavenging activity RSA, reducing power assay RPA, and total antioxidant capacity TAC assay, were adopted. The results showed that compound 2 was found to be more potent antioxidant as compared to 1. Fascinatingly, compound 2 displayed better EC50 results as compared to -tocopherol while being comparable with ascorbic acid. The antiplasmodial assay data showed that both the compound exhibited good activity against chloroquine sensitive strain of Plasmodium falciparum D10 and IC50 values were found to be less than 8 μM. The in silico molecular docking analyses were also performed for the determination of binding affinity of the isolated compounds using P. falciparum proteins PfLDH and Pfg27. The results showed that compound 2 has high docking score and binding affinity to both protein receptors as compared to compound 1. The demonstrated biological potentials declared that compound 2 could be the better natural antioxidant and antiplasmodial candidate.

Autor: Hamayun Khan, Hazrat Amin, Asad Ullah, Sumbal Saba, Jamal Rafique, Khalid Khan, Nasir Ahmad, and Syed Lal Badshah



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