Fecal Calprotectin in Healthy Children Aged 1-4 YearsReportar como inadecuado




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Objective

Calprotectin has been well emulated recently in adults as well as in children. The aim of this study was to assess fecal calprotectin concentrations in healthy children aged from 1 to 4 years.

Methods

Volunteers were enlisted from 3 nurseries. A brief questionnaire was used to ensure these children meet the inclusion criteria, and some clinical and sociodemographic factors were collected. Anthro software version 3.1 was used to calculated Length-for-age Z-scores LAZ, weight-for-age Z-scores WAZ, and weight-for-length Z-scores WLZ respectively. Fecal calprotectin was detected by a commercially available ELISA.

Results

In total 274 children were recruited, with age ranging from 1 to 4 years old. The median FC concentration was 83.19 μg-g range 4.58 to 702.50 μg-g, interquartile range IQR 14.69–419.45 μg-g or 1.92 log10 μg-g range 0.66 log10 to 2.85 log10 μg-g, IQR 1.17 log10-2.62 log10 μg-g. All of the children were divided into three groups, 1–2 years 12–24 months, 2–3 years 24–36 months, 3–4 years 36–48 months, with median FC concentrations 96.14 μg-g 1.98 log10 μg-g, 81.48 μg-g 1.91 log10 μg-g, 65.36 μg-g 1.82 log10 μg-g, respectively. There was similar FC level between boys and girls. FC concentrations showed a downward trend by the growing age groups. A statistic difference was found in FC concentrations among groups 1–2 years, 2–3 years and 3–4 years P = 0.016. In inter-groups comparison, a significant difference was found between children aged 1–2 years and children aged 3–4 years P = 0.007. A negative correlation trend was found between age and FC concentration Spearman-s rho = -0.167, P = 0.005 in all the participants. A simple correlation was performed among WLZ, WAZ, birth weight, or birth length with FC, and there was no correlation being observed.

Conclusion

Children aged from 1 to 4 years old have lower FC concentrations compared with healthy infants <1years, and higher FC concentrations when comparing with children older than 4 years and adults.



Autor: Qingling Zhu, Feng Li, Junli Wang, Lixiao Shen, Xiaoyang Sheng

Fuente: http://plos.srce.hr/



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