Relationship between G1287A of the NET Gene Polymorphisms and Brain Volume in Major Depressive Disorder: A Voxel-Based MRI StudyReportar como inadecuado




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Background

Earlier studies implicated norepinephrine transporter NET gene SLC6A2 polymorphisms in the etiology of major depressive disorder MDD. Recently, two single nucleotide SLC6A2 polymorphisms, G1287A in exon 9 and T-182C in the promoter region, were found to be associated with MDD in different populations. We investigated the relationship between the brain volume and these two polymorphisms of the SLC6A2 in MDD patients.

Methods

We obtained 3D high-resolution T1-weighted images of 30 first-episode MDD patients and 48 age- and sex-matched healthy subjects HS. All were divided into 4 groups based on polymorphism of either the G1287A or the T-182C genotype. VBM analysis examined the effects of diagnosis, genotype, and genotype-diagnosis interactions.

Results

Diagnosis effects on the brain morphology were found in the left superior temporal cortex. No significant genotype effects were found in the T-182C and the G1287A. A significant genotype G1287A–diagnosis interaction was found in the left dorsolateral prefrontal cortex. No significant genotype T-182C–diagnosis interaction effects were observed in any brain region.

Conclusions

In MDD patients there seems to be a relationship between the volume of the dorsolateral prefrontal cortex and polymorphism of the SLC6A2 G1287A gene.



Autor: Issei Ueda, Shingo Kakeda, Keita Watanabe , Reiji Yoshimura, Taro Kishi, Osamu Abe, Satoru Ide, Junji Moriya, Asuka Katsuki, Hika

Fuente: http://plos.srce.hr/



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