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Case Reports in Veterinary MedicineVolume 2014 2014, Article ID 817930, 4 pages

Case Report

Department of Veterinary Clinic, School of Veterinary Medicine and Animal Science, Universidade Estadual Paulista, Botucatu, SP, Brazil

Department of Veterinary Medicine, Federal University of Southern Border, Realeza, PR, Brazil

Department of Veterinary Medicine, University of Franca, Franca, SP, Brazil

Received 30 October 2013; Accepted 22 December 2013; Published 12 February 2014

Academic Editors: C. Hyun, C. M. Loiacono, and M. T. Mandara

Copyright © 2014 Carlos Eduardo Fonseca-Alves et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 10-year-old, intact male, pinscher was presented with unilateral bloodstained nasal discharge, sneezing, dyspnea, zygomatic arch deformity, submandibular lymph node increase, blindness in right eye, and exophthalmia. After clinical examination, it was found that the animal presented with upper respiratory tract dyspnea origin, possibly caused by an obstructive process. Complete blood count CBC, ocular ultrasonography, thoracic radiographs, mandibular lymph node, and nasal sinus fine needle aspiration were performed. The right mandibular lymph node excisional biopsy was conducted and a tumor sample was obtained through the nasal fistula at hard palate. The material was processed, paraffin embedded, sectioned, and stained with hematoxylin and eosin. Immunohistochemical staining for cytokeratin AE1-AE3, vimentin, and COX-2 was performed. After histopathological evaluation nasal carcinoma diagnosis was obtained. Chemotherapy was established with carboplatin 300 mg-m

intravenously—four cycles with intervals of 21 days—and firocoxib 5 mg-kg orally every 24 hours for 7 months. After 7 months the treatment started, the animal presented with ataxia, vocalization, hyperesthesia, and anorexia. Due the clinical condition presented, the animal owner opted for performing euthanasia. The chemotherapy protocol was effective causing the disease stagnation, minimizing the clinical signs, and extending patient survival and quality of life.

Autor: Carlos Eduardo Fonseca-Alves, Aline Gonçalves Corrêa, Fabiana Elias, and Sabryna Gouveia Calazans



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