Young Cervical Cancer Patients May Be More Responsive than Older Patients to Neoadjuvant Chemotherapy Followed by Radical SurgeryReportar como inadecuado




Young Cervical Cancer Patients May Be More Responsive than Older Patients to Neoadjuvant Chemotherapy Followed by Radical Surgery - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Objective

To evaluate the effects of age and the clinical response to neoadjuvant chemotherapy NACT in patients with cervical cancer who received neoadjuvant chemotherapy followed by radical surgery.

Methods

A total of 1,014 patients with advanced cervical cancer who received NACT followed by radical surgery were retrospectively selected. Patients were divided into young aged ≤35 years, n = 177 and older aged >35 years, n = 837 groups. We compared the short-term responses and survival rates between the groups. The five-year disease-free survival DFS and overall survival OS rates were stratified by age, NACT response, and FIGO stage.

Results

The overall response rate was 86.8% in the young group and 80.9% in the older group. The young patients had an earlier FIGO stage P<0.001, a higher rate of adenocarcinoma P = 0.022, and more lymph node metastasis P = 0.033 than the older patients. The presence of adenocarcinoma as the histological type P = 0.024 and positive lymph node metastasis P<0.001 were identified as independent risk factors for survival. When stratified by age and clinical response, young patients with no response to NACT had a worse clinicopathological condition compared with the other subgroups. Compared with non-responders, responders to NACT had a higher five-year DFS rate 80.1% versus 71.8%; P = 0.019 and OS rate 82.6% versus 71.8%; P = 0.003 among the young patients but not among the older patients.

Conclusions

Responders to NACT aged 35 years or younger benefitted the most from NACT, while the young non-responders benefitted the least. Age might represent an important factor to consider when performing NACT in patients with cervical cancer.



Autor: Jin Zhou , Xiong Li , Kecheng Huang, Yao Jia, Fangxu Tang, Haiying Sun, Yuan Zhang, Qinghua Zhang , Ding Ma , Shuang Li

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados