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BioMed Research InternationalVolume 2014 2014, Article ID 102648, 14 pages

Research Article

Graduate School of Science and Engineering, Yamagata University, Jonan 4-3-16, Yonezawa, Yamagata 992-8510, Japan

Graduate School of Dentistry, Division of Periodontology and Endodontology, Tohoku University, Seiryo-machi 4-1, Sendai, Miyagi 980-8575, Japan

Received 15 May 2014; Accepted 29 June 2014; Published 6 August 2014

Academic Editor: David M. Dohan Ehrenfest

Copyright © 2014 Erika Kitakami et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Human periodontal ligament PDL cells obtained from extracted teeth are a potential cell source for tissue engineering. We previously reported that poly2-methoxyethyl acrylate PMEA is highly biocompatible with human blood cells. In this study, we investigated the adhesion, morphology, and proliferation of PDL cells on PMEA and other types of polymers to design an appropriate scaffold for tissue engineering. PDL cells adhered and proliferated on all investigated polymer surfaces except for poly2-hydroxyethyl methacrylate and poly2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate. The initial adhesion of the PDL cells on PMEA was comparable with that on polyethylene terephthalate PET. In addition, the PDL cells on PMEA spread well and exhibited proliferation behavior similar to that observed on PET. In contrast, platelets hardly adhered to PMEA. PMEA is therefore expected to be an excellent scaffold for tissue engineering and for culturing tissue-derived cells in a blood-rich environment.

Autor: Erika Kitakami, Makiko Aoki, Chikako Sato, Hiroshi Ishihata, and Masaru Tanaka



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