An Optical Section-Assisted In Vivo Rabbit Model for Capsular Bend and Posterior Capsule Opacification InvestigationReport as inadecuate

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To establish an optical section-assisted in vivo rabbit model for capsular bend and posterior capsule opacification PCO investigation.


A total of 10 rabbits underwent phacoemulsification surgery and intraocular lens IOL implantation. On the basis of the relationship between the anterior capsule and IOL, the rabbits were divided into complete overlap and incomplete overlap groups, in which six and four rabbits were included, respectively. The capsular bend optical sections were assessed using ultra-long scan depth optical coherence tomography UL-OCT, and posterior capsule opacification was evaluated with slit lamp on postoperative day 3, 7, 14, and 28. In addition, histopathological section was used to verify the accuracy of capsular bend type captured by OCT in three rabbits.


Based on the special animal model, six capsular bend types were observed, namely, anterior A, middle M, posterior P, detachment D, funnel Fun and furcate adhesion Fur. On day 3, capsular bend began to form. On 14 days, the capsular bends were comprised of A, M and D types, which were almost maintained until day 28. Histopathological section findings were consistent with optical sectioning results. In the incomplete and complete groups, the earliest PCO within the optical zone were on day 7 and 28, respectively. The incomplete group exhibited higher incidence and faster PCO on day 7 p = 0.038 and 14 p = 0.002.


This animal model not only mimics capsular bend evolution and PCO processes but also produces OCT optical section images equivalent to and more repeatable than histopathology, thereby providing a promising method for the further investigations of PCO.

Author: Pingjun Chang , Lei Lin , Qian Zheng, Fang Yu, Xiaoyu Yu, Yinying Zhao, Xixia Ding, Weigen Zhu, Jin Li , Yun-e Zhao



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