Identification of an HIV-1 BG Intersubtype Recombinant Form CRF73 BG, Partially Related to CRF14 BG, Which Is Circulating in Portugal and SpainReportar como inadecuado




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HIV-1 exhibits a characteristically high genetic diversity, with the M group, responsible for the pandemic, being classified into nine subtypes, 72 circulating recombinant forms CRFs and numerous unique recombinant forms URFs. Here we characterize the near full-length genome sequence of an HIV-1 BG intersubtype recombinant virus X3208 collected in Galicia Northwest Spain which exhibits a mosaic structure coincident with that of a previously characterized BG recombinant virus 9601 01, collected in Germany and epidemiologically linked to Portugal, and different from currently defined CRFs. Similar recombination patterns were found in partial genome sequences from three other BG recombinant viruses, one newly derived, from a virus collected in Spain, and two retrieved from databases, collected in France and Portugal, respectively. Breakpoint coincidence and clustering in phylogenetic trees of these epidemiologically-unlinked viruses allow to define a new HIV-1 CRF CRF73 BG. CRF73 BG shares one breakpoint in the envelope with CRF14 BG, which circulates in Portugal and Spain, and groups with it in a subtype B envelope fragment, but the greatest part of its genome does not appear to derive from CRF14 BG, although both CRFs share as parental strain the subtype G variant circulating in the Iberian Peninsula. Phylogenetic clustering of partial pol and env segments from viruses collected in Portugal and Spain with X3208 and 9691 01 indicates that CRF73 BG is circulating in both countries, with proportions of around 2–3% Portuguese database HIV-1 isolates clustering with CRF73 BG. The fact that an HIV-1 recombinant virus characterized ten years ago as a URF has been shown to represent a CRF suggests that the number of HIV-1 CRFs may be much greater than currently known.



Autor: Aurora Fernández-García, Elena Delgado, María Teresa Cuevas, Yolanda Vega, Vanessa Montero, Mónica Sánchez, Cristina Carrera

Fuente: http://plos.srce.hr/



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