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Evidence-Based Complementary and Alternative MedicineVolume 2013 2013, Article ID 742476, 9 pages

Research Article

Department of Biochemistry, University of Ilorin, Ilorin, Nigeria

Department of Physiology, University of Ilorin, Ilorin, Nigeria

Department of Microbiology, University of Ilorin, Ilorin, Nigeria

Department of Chemistry, University of Ilorin, Ilorin, Nigeria

Department of Hematology, University of Ilorin, Ilorin, Nigeria

Department of Anatomy, University of Ilorin, Ilorin, Nigeria

Programa de Pós Graduação em Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100 MG, Brazil

Laboratório de Malária, Centro de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte, 30130-100 MG, Brazil

Received 26 January 2013; Revised 6 June 2013; Accepted 13 June 2013

Academic Editor: Liliana V. Muschietti

Copyright © 2013 J. O. Adebayo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In this study, the antimalarial and toxicity potentials of husk fibre extracts of five Nigerian varieties of Cocos nucifera were evaluated in vitro. The only active extract fraction, West African Tall WAT ethyl acetate extract fraction, was then evaluated for its phytochemical constituents, antimalarial and toxicity potentials at varying doses 31.25–500 mg-kg body weight using various organ function indices. The results revealed that WAT ethyl acetate extract fraction WATEAEF contained alkaloids, tannins, and flavonoids and was active against Plasmodium falciparum W2 strain maintained in continuous culture, with a selectivity index of 30.3. The same extract fraction was active in vivo against Plasmodium berghei NK65, causing more than 50% reduction in parasitaemia on days 4 and 6 after inoculation at various doses administered. WATEAEF did not significantly alter function indices of the liver and cardiovascular system at all doses administered but significantly increased plasma creatinine concentration at 250 and 500 mg-Kg body weight compared to controls. The results of this study suggest that WATEAEF possesses antimalarial activity and may not adversely affect normal liver function nor predispose subjects to cardiovascular diseases but may impair normal kidney function at higher doses. Further studies are underway to isolate the active principles.





Autor: J. O. Adebayo, E. A. Balogun, S. O. Malomo, A. O. Soladoye, L. A. Olatunji, O. M. Kolawole, O. S. Oguntoye, A. S. Babatunde

Fuente: https://www.hindawi.com/



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