Association between Parathyroid Hormone Levels and Inflammatory Markers among US AdultsReport as inadecuate

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Mediators of Inflammation - Volume 2014 2014, Article ID 709024, 8 pages -

Clinical Study

Department of Surgery, Mackay Memorial Hospital and Mackay Medical College, 92 Chung-Shan North Road, Section 2, Taipei 10449, Taiwan

Mackay Junior College of Medicine, Nursing and Management, 92 Shengjing Road, Taipei 11260, Taiwan

Department of Pharmacology and Graduate Institute of Medical Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan

Institute of Statistical Science, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 11529, Taiwan

Received 11 December 2013; Accepted 27 February 2014; Published 23 March 2014

Academic Editor: Dianne Cooper

Copyright © 2014 Shih-Ping Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Aims. High levels of parathyroid hormone PTH appear to be associated with an increased mortality. Previous studies concerning the relationship of inflammatory markers with hyperparathyroidism have yielded inconsistent results. This study investigated whether serum PTH concentrations were independently associated with several inflammatory markers among the US adults. Materials and Methods. Using data from the National Health and Nutrition Examination Survey, we examined the relation between serum PTH and C-reactive protein CRP, red cell distribution width RDW, and platelet-to-lymphocyte ratio PLR levels with weighted linear regression. Additionally, we examined the relation with increased modified Glasgow Prognostic Score mGPS by using weighted logistic regression. Results. CRP, RDW, and PLR values increased with increasing serum PTH concentration. After extensively adjusting for covariates, CRP and RDW increased linearly and across PTH categories all , while PLR marginally increased and using PTH as a categorical and continuous variable, resp

The odds ratio of increased mGPS was 1.11 and 1.31 across PTH categories and with increasing PTH levels continuously. Conclusion. These nationally representative data indicate that serum PTH levels are independently associated with several inflammatory markers in the US population. The casual relationship between PTH levels and inflammation remains to be elucidated.

Author: Shih-Ping Cheng, Chien-Liang Liu, Tsang-Pai Liu, Yi-Chiung Hsu, and Jie-Jen Lee



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