Micronuclei and other nuclear anomalies in buccal epithelial cells of children with chronic kidney diseaseReportar como inadecuado




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Archives of Industrial Hygiene and Toxicology, Vol.67 No.4 December 2016. -

The objective of this study was to reveal the likely genomic instability in children with chronic kidney disease CKD using micronucleus MN assay on buccal epithelial cells BEC. We investigated the frequencies of micronuclei and other nuclear anomalies, such as nuclear buds, binucleated cells, condensed chromatin, and karyorrhectic and pyknotic cells in BEC. Children with CKD were grouped as follows: children in the pre-dialysis PreD stage N=17, children on regular haemodialysis HD N=14, and children who have undergone transplantation Tx N=17. As a control group, twenty age- and gender-matched healthy children were selected. The MN frequency in BEC of all groups of children with CKD was significantly elevated 5- to 7-fold as compared to the control group p



Autor: Banu Aykanat - ; Department of Toxicology, Faculty of Pharmacy, Faculty of Medicine, Baskent University, Ankara, Turkey Gonca Cak

Fuente: http://hrcak.srce.hr/



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