Association between the TP53 and CYP2E1*5B gene polymorphisms and non-small cell lung cancerReportar como inadecuado

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Archives of Industrial Hygiene and Toxicology, Vol.67 No.4 December 2016. -

Non-small cell lung cancer NSCLC is the most common form of lung cancer. Genetic polymorphisms in tumour suppressor genes and genes encoding xenobiotic metabolising enzymes alter the activity of their corresponding enzymes and are important individual susceptibility factors for NSCLC. Because of the lack of information in literature, the aim of our study was to investigate the role of the tumour suppressor gene TP53 Arg72Pro and the xenobiotic metabolizing CYP2E1*5B gene polymorphisms on the risk of NSCLC development. The study population consisted of 172 patients and 172 controls 156 men and 16 women in each group. Genetic polymorphisms were determined with real-time polymerase chain reaction PCR and PCR restriction fragment length polymorphism PCR-RFLP. Multivariate analysis showed a significant association with NSCLC for the combination between the TP53 codon72 Arg-Pro and the Pro-Pro genotypes OR 2.21, 95 % CI 1.39–3.51; p=0.001. We also analysed whether combinations of these gene variants with GSTM1, GSTT1, GSTP1 exon 5 Ile105Val, and GSTP1 exon 6 Ala114Val gene polymorphisms were associated with the NSCLC risk. A significant increase in the risk was observed for the following combinations: TP53 codon72 variant with GSTM1 null OR 2.22, 95 % CI 1.23-4.04; p=0.009, GSTT1 null OR 2.98, 95 % CI 1.49-5.94; p=0.002, and GSTP1 Ala114Val variant genotypes OR 3.38, 95 % CI 1.54-7.41; p=0.002. Further studies with larger samples are needed to verify these findings.

carcinogen metabolism; CYP2E1; genetic polymorphism; GST; NSCLC

Autor: Ahmet Oguz Ada - ; Department of Toxicology, Faculty of Pharmacy, University of Ankara, Ankara, Turkey Serdar Bilgen - ; Departme



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