Helicobacter pylori in sedentarymen is linked to higher heart rate, sympathetic activity, and insulin resistance but not inflammation or oxidative stressReportar como inadecuado




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Croatian medical journal, Vol.57 No.2 April 2016. -

Aim To compare anthropometric parameters, body composition,

hormonal and inflammatory profiles, oxidative

stress indices, and heart rate variability HRV in Heliobacter

pylori H.pylori positive and negative healthy sedentary

participants.

Methods Among 30 recruited apparently healthy male

participants age between 20 and 40 enrolled in this

cross-sectional study, 18 were H.pylori negative and 12

were positive stool antigen test. Participants underwent

routine physical examination and body composition determination.

The following biochemical parameters were

determined in blood: fasting whole blood glucose, glycated

hemoglobin, insulin, C-peptide, cortisol, aldosterone,

testosterone, thyroid stimulating hormone, C-reactive protein,

interleukins 6 and 10, tumor necrosis factor-α, and the

urinary level of 1,4-dihydroxynonane mercapturic acid. For

HRV evaluation, electrocardiogram in supine position and

in orthostatic test was performed.

Results H.pylori contamination was not significantly associated

with any changes in anthropometric parameters,

body composition, blood pressure, fasting glucose,

or glycated hemoglobin levels. No significant difference

was found for inflammatory markers as well as 1,4-dihydroxynonane

mercapturic acid. H.pylori-positive participants,

however, had significantly higher heart rate

P = 0.009, sympathetic-parasympathetic balance in orthostatic

test P = 0.029, fasting insulin level P = 0.037, and

HOMA-index P = 0.047.

Conclusions H.pylori contamination is linked to a significantly

higher heart rate, sympathetic activation, and increased

insulin resistance, while inflammatory and oxidative

stress markers remain unaffected in healthy sedentary

male subjects.



Autor: Andriy Cherkas - orcid.org-0000-0002-6652-6983 ; Department of Internal Medicine No.1, Danylo Halytskyi Lviv National Medical Uni

Fuente: http://hrcak.srce.hr/



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