The effects of anthocyaninrich wheat diet on the oxidative status and behavior of ratsReport as inadecuate

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Croatian medical journal, Vol.57 No.2 April 2016. -

Aim To evaluate the effect of food containing anthocyanin-

rich wheat on oxidative status and behavior of healthy


Methods Twenty male rats were divided into the control

and anthocyanin group. Oral glucose tolerance test was

performed, and proteinuria and creatinine clearance were

measured. Behavioral analysis was performed in Phenotyper

cages. Serum and tissues were collected to measure

the markers of oxidative stress and antioxidant status.

Results Anthocyanins significantly increased total antioxidant

capacity in serum P = 0.039, decreased advanced

oxidation protein products in the kidney P = 0.002, but

increased thiobarbituric acid reactive substances in the

kidney compared to the control group. No significant difference

between the groups was found in the markers

of oxidative stress in the liver and colon, as well as in renal

functions and glucose metabolism. The anthocyanin

group spent significantly less time in the spotlight zone of

the Phenotyper cages P = 0.040, indicating higher anxiety-

like behavior.

Conclusion Food containing anthocyanin-rich wheat had

positive effects on serum antioxidant status and kidney

protein oxidation, but increased lipid peroxidation in the

kidney and modified animal behavior related to anxiety.

The molecular mechanisms leading to observed effects

should be further elucidated.

Author: Katarína Janšáková - ; Institute of Molecular Biomedicine Faculty of Medicine, Comenius University, Bratislava, Slovakia Jank



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