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Gastroenterology Research and PracticeVolume 2013 2013, Article ID 814214, 8 pages

Research Article

Gastroenterology Division, Odawara City Hospital, 46 Hisano, Odawara 250-8558, Japan

Gastroenterology Division, Yokohama City University School of Medicine, 3-9 Fuku-ura, Kanazawa-ku, Yokohama 236-0004, Japan

Gastroenterology Division, Chigasaki City Hospital, 1-15-5 Honson, Chigasaki 253-0042, Japan

Gastroenterology Division, Yokohama Rosai Hospital, 3211 Kodukue-cho, Kohoku-ku, Yokohama 222-0036, Japan

Received 30 November 2012; Accepted 5 July 2013

Academic Editor: Sergio Morini

Copyright © 2013 Harunobu Kawamura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Obscure gastrointestinal bleeding OGIB is one of the common complications in patients with chronic kidney disease CKD, especially those who are on maintenance hemodialysis HD. However, little is known about the characteristics of the small-bowel lesions in these patients, or of the factors that could predict the presence of such lesions. Therefore we enrolled a total of 42 CKD patients including 19 HD patients and 23 non-HD patients, and compared the incidence of the small-bowel lesions among two groups. Furthermore, to identify predictive factors for the presence of small-bowel lesions, we performed multivariate logistic-regression-analyses. The incidence of small-bowel vascular lesions was significantly higher in CKD patients than in age-and-sex matched non-CKD patients . On the other hand, there was any significant difference of the incidence of small-bowel lesions between HD and non-HD patients. In CKD patients, past history of blood transfusion OR 5.66; 95% CI 1.10–29.1, was identified as an independent predictor of the presence of vascular lesions, and history of low-dose aspirin use OR 6.00; 95% CI 1.13–31.9, was identified as that of erosive-ulcerated lesions. This indicated that proactive CE examination would be clinically meaningful for these patients.

Author: Harunobu Kawamura, Eiji Sakai, Hiroki Endo, Leo Taniguchi, Yasuo Hata, Akiko Ezuka, Hajime Nagase, Takaomi Kessoku, Eiji Y



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