Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol ConjugateReportar como inadecuado




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Croatica Chemica Acta, Vol.89 No.3 September 2016. -

The bioorganometallic III containing trimethylene chain between ferrocene and resveratrol 3,5,4-trihydroxystilbene, RSV moieties connected via ester bond has been synthesized. The novel bioconjugate was characterized using IR and NMR 1H, 13C, COSY, NOESY, HMBC spectroscopy, ESI-MS and HRMS. The RSV and ferrocene-RSV conjugate III were screened in vitro for their inhibitory effects against proliferation of hepatoblastoma Hep G2 cells by MTT assay. Also, possible cytotoxicity towards normal ovary cells CHO-K1 was evaluated. The obtained data revealed profound effects in biological-cytotoxic activity of III vs. RSV in Hep G2 cell line. Lower cytotoxicity of III was observed in normal ovary cells as compared to hepatoblastoma cells.

This work is licensed under a Creative Commons Attribution 4.0 International License.

ferrocene; ferrocene-resveratrol conjugate; hepatoblastoma; normal ovary cells; resveratrol



Autor: Veronika Kovač - orcid.org-0000-0001-9538-6724 ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotec

Fuente: http://hrcak.srce.hr/



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