Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol ConjugateReport as inadecuate

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Croatica Chemica Acta, Vol.89 No.3 September 2016. -

The bioorganometallic III containing trimethylene chain between ferrocene and resveratrol 3,5,4-trihydroxystilbene, RSV moieties connected via ester bond has been synthesized. The novel bioconjugate was characterized using IR and NMR 1H, 13C, COSY, NOESY, HMBC spectroscopy, ESI-MS and HRMS. The RSV and ferrocene-RSV conjugate III were screened in vitro for their inhibitory effects against proliferation of hepatoblastoma Hep G2 cells by MTT assay. Also, possible cytotoxicity towards normal ovary cells CHO-K1 was evaluated. The obtained data revealed profound effects in biological-cytotoxic activity of III vs. RSV in Hep G2 cell line. Lower cytotoxicity of III was observed in normal ovary cells as compared to hepatoblastoma cells.

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ferrocene; ferrocene-resveratrol conjugate; hepatoblastoma; normal ovary cells; resveratrol

Author: Veronika Kovač - orcid.org-0000-0001-9538-6724 ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotec

Source: http://hrcak.srce.hr/


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