Does AMH Reflect Follicle Number Similarly in Women with and without PCOSReportar como inadecuado




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Context

Increased Anti-Mullerian Hormone in polycystic ovary syndrome, may be due to overactive follicles rather than reflect antral follicle count.

Objective

Does Anti-Mullerian Hormone reflect antral follicle count similarly in women with or without polycystic ovary syndrome or polycystic ovarian morphology?

Design

Cross-sectional, case-control.

Setting

Women who delivered preterm in 1999–2006. For each index woman, a woman with a term delivery was identified.

Patients

Participation rate was 69%. Between 2006–2008, 262 women were included, and diagnosed to have polycystic ovary syndrome, polycystic ovarian morphology or to be normal controls.

Interventions

Blood tests, a clinical examination and vaginal ultrasound.

Main Outcome Measures

Anti-Mullerian Hormone - antral follicle count -ratio, SHBG, androstenedione and insulin, to test potential influence on the Anti-Mullerian Hormone - antral follicle count -ratio.

Results

Mean Anti-Mullerian Hormone - antral follicle count ratio in women with polycystic ovary syndrome or polycystic ovarian morphology was similar to that of the controls polycystic ovary syndrome: 1,2 p = 0,10 polycystic ovarian morphology: 1,2, p = 0,27 Controls 1,3. Anti-Mullerian Hormone showed a positive linear correlation to antral follicle count in all groups. Multivariate analysis did not change the results.

Conclusions

We confirmed the positive correlation between AMH and follicle count. Anti-Mullerian Hormone seems to be a reliable predictor of antral follicle count, independent of polycystic ovary syndrome diagnosis or ovarian morphology.



Autor: Sverre C. Christiansen , Tina B. Eilertsen, Eszter Vanky, Sven M. Carlsen

Fuente: http://plos.srce.hr/



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