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BioMed Research InternationalVolume 2014 2014, Article ID 814208, 23 pages

Review Article

Department of Drug Development, College of Medicine, Inha University, 3-ga, Sinheung dong, Jung-gu, Incheon 400-712, Republic of Korea

Department of Bioengineering, University of California, Berkeley and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA

Received 25 November 2013; Accepted 25 December 2013; Published 19 February 2014

Academic Editor: Dong-Wook Han

Copyright © 2014 Su-Eon Jin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Targeted delivery systems of nanobiomaterials are necessary to be developed for the diagnosis and treatment of cancer. Nanobiomaterials can be engineered to recognize cancer-specific receptors at the cellular levels and to deliver anticancer drugs into the diseased sites. In particular, nanobiomaterial-based nanocarriers, so-called nanoplatforms, are the design of the targeted delivery systems such as liposomes, polymeric nanoparticles-micelles, nanoconjugates, norganic materials, carbon-based nanobiomaterials, and bioinspired phage system, which are based on the nanosize of 1–100 nm in diameter. In this review, the design and the application of these nanoplatforms are discussed at the cellular levels as well as in the clinics. We believe that this review can offer recent advances in the targeted delivery systems of nanobiomaterials regarding in vitro and in vivo applications and the translation of nanobiomaterials to nanomedicine in anticancer therapy.

Autor: Su-Eon Jin, Hyo-Eon Jin, and Soon-Sun Hong



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