Expression of CTRP3, a Novel Adipokine, in Rats at Different Pathogenic Stages of Type 2 Diabetes Mellitus and the Impacts of GLP-1 Receptor Agonist on ItReportar como inadecuado




Expression of CTRP3, a Novel Adipokine, in Rats at Different Pathogenic Stages of Type 2 Diabetes Mellitus and the Impacts of GLP-1 Receptor Agonist on It - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Diabetes ResearchVolume 2014 2014, Article ID 398518, 6 pages

Research Article

Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China

Department of Internal Medicine, Zhongnan Hospital, Wuhan University, Wuhan 430071, China

Received 17 June 2014; Revised 19 July 2014; Accepted 24 July 2014; Published 11 August 2014

Academic Editor: Tomohiko Sasase

Copyright © 2014 Xin Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study aimed to investigate the expression of C1q-TNF-related protein-3 CTRP3 in rats at different pathogenic stages of type 2 diabetes mellitus T2DM and the impacts of glucagon-like peptide-1 GLP-1 receptor agonist on it. Male wistar rats were fed with high-fat diet for 10 weeks to induce insulin resistance IR and then were given low-dose streptozotocin STZ intraperitoneal injection to induce T2DM. Exendin-4 Ex-4, a GLP-1 receptor agonist, was subcutaneous injected to the IR rats and T2DM rats for 4 weeks. The expression of CTRP3 mRNA and protein in epididymis adipose tissue of rats at the stage of IR was lower significantly than that of normal control NC rats and decreased more when they were at the stage of overt T2DM all or . After the treatment with Ex-4, the mRNA and protein expressions of CTRP3 were increased by 15.5% and 14.8% respectively, in IR rats and increased by 20.6% and 16.5% respectively, in T2DM rats. Overall, this study found that the expression of CTRP3 in visceral adipose tissue was progressively decreased in a T2DM rat model from the pathogenic stage of IR to overt diabetes, while Ex-4 treatment increased its expression in such animals.





Autor: Xin Li, Li Jiang, Miao Yang, Yu-wen Wu, Su-xin Sun, and Jia-zhong Sun

Fuente: https://www.hindawi.com/



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