S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain CancersReportar como inadecuado




S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

This study examined the value of blood marker S100A1 in detecting cardiotoxicity induced by chemotherapy agents; trastuzumab and lapatinib, in normal rat heart. The rats were divided into three groups: control n = 8, no treatment, T n = 8, one time ip treatment with 10 mg-kg trastuzumab and L n = 8, oral treatment with 100 mg-kg-day lapatinib for 7 days. The activities of oxidative stress parameters Malondialdehyde MDA, Superoxide dismutase SOD, Catalase CAT and Glutathione GSH were measured from the extracted cardiac tissues. The levels of troponinI and S100A1 expressions were measured from blood samples. All biomarkers responded to the treatments as they exhibited alterations from their normative values, validating the chemically induced cardiotoxicity. S100A1 expression attenuated significantly 75%, which made the sensitive detection of cardiotoxicity feasible. Assessment of cardiotoxicity with S100A1 may be a valuable alternative in clinical oncology of cancers in some organs such as breast and prostate, as they do not overexpress it to compete against.



Autor: Ufuk Eryilmaz , Buket Demirci, Saliha Aksun, Murat Boyacioglu, Cagdas Akgullu, Tevfik Fikret Ilgenli, Hande Sultan Yalinkilinc, M

Fuente: http://plos.srce.hr/



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