Neural Hyperactivity of the Central Auditory System in Response to Peripheral DamageReportar como inadecuado

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Neural Plasticity - Volume 2016 2016, Article ID 2162105, 9 pages -

Review ArticleDepartment of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China

Received 28 August 2015; Revised 12 November 2015; Accepted 15 November 2015

Academic Editor: Aage R. Moller

Copyright © 2016 Yi Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


It is increasingly appreciated that cochlear pathology is accompanied by adaptive responses in the central auditory system. The cause of cochlear pathology varies widely, and it seems that few commonalities can be drawn. In fact, despite intricate internal neuroplasticity and diverse external symptoms, several classical injury models provide a feasible path to locate responses to different peripheral cochlear lesions. In these cases, hair cell damage may lead to considerable hyperactivity in the central auditory pathways, mediated by a reduction in inhibition, which may underlie some clinical symptoms associated with hearing loss, such as tinnitus. Homeostatic plasticity, the most discussed and acknowledged mechanism in recent years, is most likely responsible for excited central activity following cochlear damage.

Autor: Yi Zhao, Qiang Song, Xinyi Li, and Chunyan Li



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