NKG2D and DNAM-1 Ligands: Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple MyelomaReportar como inadecuado




NKG2D and DNAM-1 Ligands: Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BioMed Research International - Volume 2015 2015, Article ID 178698, 9 pages -

Review ArticleDepartment of Molecular Medicine, Pasteur Cenci-Bolognetti Foundation Institute, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, Italy

Received 17 November 2014; Accepted 26 March 2015

Academic Editor: Swaleha Zubair

Copyright © 2015 Cinzia Fionda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A pivotal strategy to improve NK cell-mediated antitumor activity involves the upregulation of activating ligands on tumor cells. Enhancement of NK cell-mediated recognition of multiple myeloma cells was reported by us and others showing increased surface expression of NKG2D and DNAM-1 ligands on tumor cells following treatment with a number of chemotherapeutic agents, such as genotoxic drugs or inhibitors of proteasome, histone deacetylases, GSK3, and HSP-90. These compounds have the capability to affect tumor survival but also to activate specific transduction pathways associated with the upregulation of different NK cell activating ligands on the tumor cells. Here, we will summarize and discuss the molecular pathways whereby these drugs can regulate the expression of NK cell activating ligands in multiple myeloma cells.





Autor: Cinzia Fionda, Alessandra Soriani, Alessandra Zingoni, Angela Santoni, and Marco Cippitelli

Fuente: https://www.hindawi.com/



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