Clinicopathological Characteristics and Survival Outcomes of Primary Signet Ring Cell Carcinoma in the Stomach: Retrospective Analysis of Single Center DatabaseReportar como inadecuado




Clinicopathological Characteristics and Survival Outcomes of Primary Signet Ring Cell Carcinoma in the Stomach: Retrospective Analysis of Single Center Database - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Purpose

To investigate the clinicopathological features and prognosis of signet ring cell carcinoma of the stomach SRC.

Methods

A total of 1464 gastric cancer patients who underwent curative gastrectomy from 2000 to 2008 at a single center were evaluated. Signet ring cell carcinoma SRC was defined as the presence of at least 50% signet ring cells in the pathologic specimen. The clinicopathological parameters and prognosis of SRC were analyzed by comparing with non-signet ring cell carcinoma NSRC.

Results

Of 1464 patients, 138 patients 9.4% were classified as SRC. There were significant differences in gender, age, tumor location, TNM stage, p21 expression, and p53 expression between SRC and NSRC. The 5-year survival rates of SRC and NSRC were 36.2% and 49.5%, respectively. The prognosis of SRC was poorer than that of NSRC P <0.001. Multivariate analysis showed that SRC histology was an independent factor for poor prognosis P <0.001.

Conclusion

Patients with SRC tend to present with a more advanced stage and poorer prognosis than patients with other types of gastric carcinoma.



Autor: Xiaowen Liu, Hong Cai, Weiqi Sheng, Lin Yu, Ziwen Long, Yingqiang Shi, Yanong Wang

Fuente: http://plos.srce.hr/



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