The Joint Effects of Lifestyle Factors and Comorbidities on the Risk of Colorectal Cancer: A Large Chinese Retrospective Case-Control StudyReport as inadecuate




The Joint Effects of Lifestyle Factors and Comorbidities on the Risk of Colorectal Cancer: A Large Chinese Retrospective Case-Control Study - Download this document for free, or read online. Document in PDF available to download.

Background

Colorectal cancer CRC is a major cause of cancer morbidity and mortality. In previous epidemiologic studies, the respective correlation between lifestyle factors and comorbidity and CRC has been extensively studied. However, little is known about their joint effects on CRC.

Methods

We conducted a retrospective case-control study of 1,144 diagnosed CRC patients and 60,549 community controls. A structured questionnaire was administered to the participants about their socio-demographic factors, anthropometric measures, comorbidity history and lifestyle factors. Logistic regression model was used to calculate the odds ratio ORs and 95% confidence intervals 95%CIs for each factor. According to the results from logistic regression model, we further developed healthy lifestyle index HLI and comorbidity history index CHI to investigate their independent and joint effects on CRC risk.

Results

Four lifestyle factors including physical activities, sleep, red meat and vegetable consumption and four types of comorbidity including diabetes, hyperlipidemia, history of inflammatory bowel disease and polyps were found to be independently associated with the risk of CRC in multivariant logistic regression model. Intriguingly, their combined pattern- HLI and CHI demonstrated significant correlation with CRC risk independently ORHLI: 3.91, 95%CI: 3.13–4.88; ORCHI: 2.49, 95%CI: 2.11–2.93 and jointly OR: 10.33, 95%CI: 6.59–16.18.

Conclusions

There are synergistic effects of lifestyle factors and comorbidity on the risk of colorectal cancer in the Chinese population.



Author: Junjie Hang , Binxin Cai , Peng Xue , Lei Wang , Hai Hu, Yangyang Zhou, Shujuan Ren, Jiajin Wu, Meiying Zhu, Donghui Chen, Haiyan

Source: http://plos.srce.hr/



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