Toona sinensis Leaf Aqueous Extract Improves the Functions of Sperm and Testes via Regulating Testicular Proteins in Rats under Oxidative StressReportar como inadecuado




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Evidence-Based Complementary and Alternative MedicineVolume 2012 2012, Article ID 681328, 10 pages

Research Article

Department of Life Sciences, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan

Department of Biotechnology, The University of Hong Kong, Taichung 433, Taiwan

Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 811, Taiwan

Department of Living Science, Tainan University of Technology, Tainan 710, Taiwan

Received 15 June 2012; Accepted 26 August 2012

Academic Editor: I-Min Liu

Copyright © 2012 Bu-Chin Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Toona sinensis leaf TSL is commonly used as a vegetable and in spice in Asia. In this study, feeding with aqueous extract of TSL TSL-A alleviated oxidative stress and recovered the motility and functions of sperm in rats under oxidative stress. Protein expressions in testes identified by proteomic analysis and verified by Western blot demonstrated that TSL-A not only downregulated the level of glutathione transferase mu6 antioxidant system, heat shock protein 90 kDa-β protein misfolding repairing system, cofilin 2 spermatogenesis, and cyclophilin A apoptosis but also upregulated crease3-hydroxy-3-methylglutaryl-coenzyme A synthase 2 steroidogenesis, heat shock glycoprotein 96, and pancreatic trypsin 1 sperm-oocyte interaction. These results indicate that TSL-A promotes the functions of sperm and testes via regulating multiple testicular proteins in rats under oxidative stress, suggesting that TSL-A is a valuable functional food supplement to improve functions of sperm and testes for males under oxidative stress.





Autor: Bu-Chin Yu, Wen-Jen Yu, Chun-Yung Huang, Ying-Hsin Chen, Yun-Ching Tsai, Chen-Chin Chang, and Sue-Joan Chang

Fuente: https://www.hindawi.com/



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