Prevalence of Toxoplasma Infection in Mexican Newborns and Children: A Systematic Review from 1954 to 2009Reportar como inadecuado

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ISRN PediatricsVolume 2012 2012, Article ID 501216, 5 pages

Research Article

Neurophysiology Laboratory, Departament of Physiology, Health Science University Center, University of Guadalajara, Sierra Mojada No. 950 Edificio N, Col. Independencia, Guadalajara, México 44320 JAL, Mexico

Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara “Fray Antonio Alcalde”, University of Guadalajara, Hospital 278, 44280 Guadalajara, JAL, Mexico

“Federico Gómez”, Hospital Infantil de México, Secretaria de Salud, Mexico

Pediatric and Epidemiology Service, Hospital Number 110 Mexican Institute of Social Security, Avenue Circunvalación Oblatos and Francisco Bocanegra, Guadalajara, JAL, Mexico

Received 2 June 2012; Accepted 7 August 2012

Academic Editors: S. Fanconi, T. Hegyi, and B. Vasarhelyi

Copyright © 2012 Ma. de la Luz Galvan-Ramírez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Recent studies in Mexico have shown that from 20-10,000 to 58-10,000 newborns with Toxoplasma infection could be undetected. The aim of this study was to determine the weighed prevalence of T. gondii infection and describe the epidemiological transition of infection in newborns. Methods. Research literature reporting Toxoplasma infection prevalence in Mexican newborns and children were searched in five international databases. Weighted prevalence was calculated by inverse variance-weighted method in asymptomatic and symptomatic study groups, and the epidemiological transition was estimated by a lineal regression analysis. Results. The weighed prevalence in 4833 asymptomatic newborns was 0.616%, CI95% 0.396%–0.835% , whereas, among 895 symptomatic newborns, the weighed prevalence was 3.02%, CI 95% 1.91%–4.1% . A downward trend of 0.25%-year represented an accumulated decrease of −13,75% in the prevalence in the symptomatic newborns throughout 55 years, whereas, in the asymptomatic children, the prevalence was similar over the course of the years. Conclusion. The high-weighted prevalence of congenital Toxoplasma infection in newborns justifies that Toxoplasma gondii testing be included in the screening programs for women during pregnancy and newborns in Mexico. A rapid diagnosis and treatment strategy could aid in limiting a potential damage to the newborns.

Autor: Ma. de la Luz Galvan-Ramírez, Rogelio Troyo-Sanroman, Sonia Roman, Rosamaría Bernal-Redondo, and José Luís Vázquez Castel



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