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Advances in HematologyVolume 2012 2012, Article ID 464680, 9 pages

Review ArticleMolecular Pathology Laboratory, Haematopathology Unit, Department of Haematology and Oncology “L. and A. Seràgnoli”, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy

Received 8 July 2011; Accepted 15 September 2011

Academic Editor: Lorenzo Leoncini

Copyright © 2012 Maura Rossi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the last years, several studies of molecular profiling of aggressive lymphomas were performed. In particular, it was shown that DLBCL can be distinguished in two different entities according to GEP. Specifically, ABC and GCB subtypes were characterized by having different pathogenetic and clinical features. In addition, it was demonstrated that DLBCLs are distinct from BL. Indeed, the latter is a unique molecular entity. However, relevant pathological differences emerged among the clinical subtypes. More recently, microRNA profiling provided further information concerning BL-DLBCL distinction as well as for their subclassification. In this paper, the authors based on their own experience and the most updated literature review, the main concept on molecular profiling of aggressive lymphomas.

Author: Maura Rossi, Maria Antonella Laginestra, Anna Gazzola, Maria Rosaria Sapienza, Stefano A. Pileri, and Pier Paolo Piccaluga



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