Association between Diabetes and Risk of Aortic Dissection: A Case-Control Study in a Chinese PopulationReportar como inadecuado




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Background

It is well-recognized that diabetes represents a powerful independent risk factor for cardiovascular diseases. However, very few studies have investigated the relationship between diabetes and risk of aortic dissection AD.

Aim

The aim of this case-control study was to evaluate the association between diabetes and risk of AD in Chinese population.

Methods

A hospital-based case-control study, consisting of 2160 AD patients and 4320 controls, was conducted in a Chinese population. Demographic, clinical characteristics and risk factors were collected. Diabetes rate of patients with overall AD, Stanford type A AD and type B AD group was compared with that of corresponding matched control groups. Logistic regression analysis was used to estimate the odds ratios OR and 95% confidence intervals 95% CI for relationship between diabetes and AD risk.

Results

The prevalence of diabetes was lower in AD cases than that of control subjects, whether it is the overall AD, type A AD or type B AD group 4.7% vs. 10.0%, 2.9% vs. 8.8%, 5.9% vs. 10.9%, all P<0.001. Furthermore, in multivariate model, diabetes was found to be associated with lower AD risk, which not only applies to the overall AD OR = 0.2, 95%CI: 0.15–0.26, but also type A AD OR = 0.12, 95% CI: 0.07–0.20 and type B AD OR = 0.25, 95%CI: 0.18–0.33.

Conclusions

We observed the paradoxical inverse relationship between DM and risk of AD in the Chinese population. These results suggest diabetes may play a protective role in the development of AD. However, further studies are needed to enrich related evidence, especially with regard to underlying mechanisms for these trends.



Autor: Xingwei He, Xintian Liu, Wanjun Liu, Bei Wang, Yujian Liu, Zhuxi Li, Tao Wang, Rong Tan, Bo Gao, Hesong Zeng

Fuente: http://plos.srce.hr/



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