Multilevel Deficiency of White Matter Connectivity Networks in Alzheimer’s Disease: A Diffusion MRI Study with DTI and HARDI ModelsReportar como inadecuado




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Neural Plasticity - Volume 2016 2016, Article ID 2947136, 14 pages -

Research Article

Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

IDEA Lab, Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Alzheimer’s Disease and Related Disorders Center, Shanghai Jiao Tong University, Shanghai, China

Department of Radiology, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea

Received 23 June 2015; Accepted 22 November 2015

Academic Editor: Clive R. Bramham

Copyright © 2016 Tao Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Alzheimer’s disease AD is the most common form of dementia in elderly people. It is an irreversible and progressive brain disease. In this paper, we utilized diffusion-weighted imaging DWI to detect abnormal topological organization of white matter WM structural networks. We compared the differences between WM connectivity characteristics at global, regional, and local levels in 26 patients with probable AD and 16 normal control NC elderly subjects, using connectivity networks constructed with the diffusion tensor imaging DTI model and the high angular resolution diffusion imaging HARDI model, respectively. At the global level, we found that the WM structural networks of both AD and NC groups had a small-world topology; however, the AD group showed a significant decrease in both global and local efficiency, but an increase in clustering coefficient and the average shortest path length. We further found that the AD patients had significantly decreased nodal efficiency at the regional level, as well as weaker connections in multiple local cortical and subcortical regions, such as precuneus, temporal lobe, hippocampus, and thalamus. The HARDI model was found to be more advantageous than the DTI model, as it was more sensitive to the deficiencies in AD at all of the three levels.





Autor: Tao Wang, Feng Shi, Yan Jin, Pew-Thian Yap, Chong-Yaw Wee, Jianye Zhang, Cece Yang, Xia Li, Shifu Xiao, and Dinggang Shen

Fuente: https://www.hindawi.com/



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