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Clinical and Developmental ImmunologyVolume 2012 2012, Article ID 258391, 10 pages

Review Article

Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan

Department of Microbiology and Immunology, National Defense Medical Center, Taipei 114, Taiwan

Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114, Taiwan

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan

Received 12 July 2011; Revised 4 September 2011; Accepted 16 September 2011

Academic Editor: Raivo Uibo

Copyright © 2012 Shyi-Jou Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The immunologic interaction between the fetus and the mother is a paradoxical communication that is regulated by fetal antigen presentation and-or by recognition of and reaction to these antigens by the maternal immune system. There have been significant advances in understanding of abnormalities in the maternal-fetal immunologic relationship in the placental bed that can lead to pregnancy disorders. Moreover, immunologic recognition of pregnancy is vital for the maintenance of gestation, and inadequate recognition of fetal antigens may cause abortion. In this paper, we illustrate the complex immunologic aspects of human reproduction in terms of the role of human leukocyte antigen HLA, immune cells, cytokines and chemokines, and the balance of immunity in pregnancy. In addition, we review the immunologic processes of human reproduction and the current immunologic therapeutic strategies for pathological disorders of pregnancy.





Autor: Shyi-Jou Chen, Yung-Liang Liu, and Huey-Kang Sytwu

Fuente: https://www.hindawi.com/



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