No Difference in Sleep and RBD between Different Types of Patients with Multiple System Atrophy: A Pilot Video-Polysomnographical StudyReportar como inadecuado




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Sleep DisordersVolume 2013 2013, Article ID 258390, 7 pages

Clinical Study

Paracelsus Elena Klinik, Klinik Straße 16, 34128 Kassel, Germany

Department of Neurosciences, University of Medicine and Pharmacy, Victor Babes Straße 43, 400012 Cluj-Napoca, Romania

Department of Neurosurgery, University of Göttingen, Robert Koch Straße 40, 37075 Göttingen, Germany

Received 17 January 2013; Revised 19 March 2013; Accepted 24 March 2013

Academic Editor: Marco Zucconi

Copyright © 2013 Maria-Lucia Muntean et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Patients with multiple system atrophy MSA, similarly to patients with alpha-synucleinopathies, can present with different sleep problems. We sought to analyze sleep problems in the two subtypes of the disease MSA cerebellar type MSA-C and MSA parkinsonian type MSA-P, paying special attention to REM sleep disturbances and periodic limb movements PLMs. Methods. In the study we included 11 MSA-C and 27 MSA-P patients who underwent one night polysomnography. For the analysis, there were 37 valid polysomnographic studies. Results. Sleep efficiency was decreased in both groups MSA-C, 64.27% ± 12.04%; MSA-P, 60.64% ± 6.01%. The PLM indices using standard measures, in sleep PLMS and while awake PLMW, were high in both groups MSA-C patients: PLMS index 72 ± 65, PLMW index 38 ± 33; MSA-P patients: PLMS index 66 ± 63, PLMW index 48 ± 37. Almost one-third of the MSA patients of both groups presented features of RLS on video-polysomnography. RBD was described in 8-11 73% patients with MSA-C and 19-25 76% patients with MSA-P . Conclusion. Our results showed very similar polysomnographic results for both MSA-P and MSA-C patients as a probable indicator for the similar pathologic mechanism of the disease and especially of its sleep problems.





Autor: Maria-Lucia Muntean, Friederike Sixel-Döring, and Claudia Trenkwalder

Fuente: https://www.hindawi.com/



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