Association of Maternal Vitamin D Status with Glucose Tolerance and Caesarean Section in a Multi-Ethnic Asian Cohort: The Growing Up in Singapore Towards Healthy Outcomes StudyReport as inadecuate




Association of Maternal Vitamin D Status with Glucose Tolerance and Caesarean Section in a Multi-Ethnic Asian Cohort: The Growing Up in Singapore Towards Healthy Outcomes Study - Download this document for free, or read online. Document in PDF available to download.

Objective

Epidemiological studies relating maternal 25-hydroxyvitamin D 25OHD with gestational diabetes mellitus GDM and mode of delivery have shown controversial results. We examined if maternal 25OHD status was associated with plasma glucose concentrations, risks of GDM and caesarean section in the Growing Up in Singapore Towards healthy Outcomes GUSTO study.

Methods

Plasma 25OHD concentrations, fasting glucose FG and 2-hour postprandial glucose 2HPPG concentrations were measured in 940 women from a Singapore mother-offspring cohort study at 26–28 weeks’ gestation. 25OHD inadequacy and adequacy were defined based on concentrations of 25OHD ≤75nmol-l and >75nmol-l respectively. Mode of delivery was obtained from hospital records. Multiple linear regression was performed to examine the association between 25OHD status and glucose concentrations, while multiple logistic regression was performed to examine the association of 25OHD status with risks of GDM and caesarean section.

Results

In total, 388 41.3% women had 25OHD inadequacy. Of these, 131 33.8%, 155 39.9% and 102 26.3% were Chinese, Malay and Indian respectively. After adjustment for confounders, maternal 25OHD inadequacy was associated with higher FG concentrations β = 0.08mmol-l, 95% Confidence Interval CI = 0.01, 0.14, but not 2HPPG concentrations and risk of GDM. A trend between 25OHD inadequacy and higher likelihood of emergency caesarean section Odds Ratio OR = 1.39, 95% CI = 0.95, 2.05 was observed. On stratification by ethnicity, the association with higher FG concentrations was significant in Malay women β = 0.19mmol-l, 95% CI = 0.04, 0.33, while risk of emergency caesarean section was greater in Chinese OR = 1.90, 95% CI = 1.06, 3.43 and Indian women OR = 2.41, 95% CI = 1.01, 5.73.

Conclusions

25OHD inadequacy is prevalent in pregnant Singaporean women, particularly among the Malay and Indian women. This is associated with higher FG concentrations in Malay women, and increased risk of emergency caesarean section in Chinese and Indian women.



Author: See Ling Loy, Ngee Lek, Fabian Yap, Shu E. Soh, Natarajan Padmapriya, Kok Hian Tan, Arijit Biswas, George Seow Heong Yeo, Kenneth

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents