Profiling of Discrete Gynecological Cancers Reveals Novel Transcriptional Modules and Common Features Shared by Other Cancer Types and Embryonic Stem CellsReport as inadecuate




Profiling of Discrete Gynecological Cancers Reveals Novel Transcriptional Modules and Common Features Shared by Other Cancer Types and Embryonic Stem Cells - Download this document for free, or read online. Document in PDF available to download.

Studies on individual types of gynecological cancers GCs, utilizing novel expression technologies, have revealed specific pathogenetic patterns and gene markers for cervical CC, endometrial EC and vulvar cancer VC. Although the clinical phenotypes of the three types of gynecological cancers are discrete, the fact they originate from a common embryological origin, has led to the hypothesis that they might share common features reflecting regression to early embryogenesis. To address this question, we performed a comprehensive comparative analysis of their profiles. Our data identified both common features pathways and networks and novel distinct modules controlling the same deregulated biological processes in all three types. Specifically, four novel transcriptional modules were discovered regulating cell cycle and apoptosis. Integration and comparison of our data with other databases, led to the identification of common features among cancer types, embryonic stem ES cells and the newly discovered cell population of squamocolumnar SC junction of the cervix, considered to host the early cancer events. Conclusively, these data lead us to propose the presence of common features among gynecological cancers, other types of cancers, ES cells and the pre-malignant SC junction cells, where the novel E2F-NFY and MAX-CEBP modules play an important role for the pathogenesis of gynecological carcinomas.



Author: Kalliopi I. Pappa , Alexander Polyzos , Jasmine Jacob-Hirsch, Ninette Amariglio, George D. Vlachos, Dimitrios Loutradis, Nicholas

Source: http://plos.srce.hr/



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