Gender Specific Association of Serum Leptin and Insulinemic Indices with Nonalcoholic Fatty Liver Disease in Prediabetic SubjectsReport as inadecuate




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Adipose tissue-derived hormone leptin plays a functional role in glucose tolerance through its effects on insulin secretion and insulin sensitivity which also represent the risk factors for nonalcoholic fatty liver disease NAFLD. The present study explored the gender specific association of serum leptin and insulinemic indices with NAFLD in Bangladeshi prediabetic subjects. Under a cross-sectional analytical design a total of 110 ultrasound examined prediabetic subjects, aged 25–68 years consisting of 57.3% male 55.6% non NAFLD and 44.4% NAFLD and 42.7% female 57.4% non NAFLD and 42.6% NAFLD, were investigated. Insulin secretory function HOMA%B and insulin sensitivity HOMA%S were calculated from homeostasis model assessment HOMA. Serum leptin showed significant positive correlation with fasting insulin r = 0.530, P = 0.004, postprandial insulin r = 0.384, P = 0.042 and HOMA-IR r = 0.541, P = 0.003 as well as significant negative correlation with HOMA%S r = -0.388, P = 0.046 and HOMA%B r = -0.356, P = 0.039 in male prediabetic subjects with NAFLD. In multiple linear regression analysis, log transformed leptin showed significant positive association with HOMA-IR β = 0.706, P <0.001 after adjusting the effects of body mass index BMI, triglyceride TG and HOMA%B in male subjects with NAFLD. In binary logistic regression analysis, only log leptin OR 1.29 95% C.I 1.11–1.51, P = 0.001 in male subjects as well as HOMA%B OR 0.94 95% C.I 0.89–0.98, P = 0.012, HOMA-IR OR 3.30 95% C.I 0.99–10.95, P = 0.049 and log leptin OR 1.10 95% C.I 1.01–1.20, P = 0.026 in female subjects were found to be independent determinants of NAFLD after adjusting the BMI and TG. Serum leptin seems to have an association with NAFLD both in male and female prediabetic subjects and this association in turn, is mediated by insulin secretory dysfunction and insulin resistance among these subjects.



Author: Israt Ara Hossain , Salima Akter, Mohammad Khalilur Rahman, Liaquat Ali

Source: http://plos.srce.hr/



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