Protective Role of Omega-3 Polyunsaturated Fatty Acid against Lead Acetate-Induced Toxicity in Liver and Kidney of Female RatsReportar como inadecuado

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BioMed Research International - Volume 2014 2014, Article ID 435857, 11 pages -

Research Article

Zoology Department, Faculty of Science, Alexandria University, Moharram Bey, Alexandria 21511, Egypt

Protein Research Department, Genetic Engineering and Biotechnology Research Institute GEBRI, City of Scientific Research and Technological Applications SRTA-City, New Borg El-Arab, Alexandria 21934, Egypt

Received 11 February 2014; Revised 30 April 2014; Accepted 21 May 2014; Published 18 June 2014

Academic Editor: Anilava Kaviraj

Copyright © 2014 Heba M. Abdou and Mohamed A. Hassan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present study was conducted to investigate the protective role of Omega-3 polyunsaturated fatty acids against lead acetate-induced toxicity in liver and kidney of female rats. Animals were divided into four equal groups; group 1 served as control while groups 2 and 3 were treated orally with Omega-3 fatty acids at doses of 125 and 260 mg-kg body weight, respectively, for 10 days. These groups were also injected with lead acetate 25 mg-kg body weight during the last 5 days. Group 4 was treated only with lead acetate for 5 days and served as positive control group. Lead acetate increased oxidative stress through an elevation in MDA associated with depletion in antioxidant enzymes activities in the tissues. Moreover, the elevation of serum enzymes activities ALT, AST, ALP, and LDH and the levels of urea and creatinine were estimated but total proteins were decreased. Also, lead acetate-treatment induced hyperlipidemia via increasing of lipid profiles associated with decline in HDL-c level. Significant changes of Hb, PCV, RBCs, PLT, and WBCs in group 4 were recorded. The biochemical alterations of lead acetate were confirmed by histopathological changes and DNA damage. The administration of Omega-3 provided significant protection against lead acetate toxicity.

Autor: Heba M. Abdou and Mohamed A. Hassan



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