Background Intestinal 18F-FDG Uptake Is Related to Serum Lipid Profile and Obesity in Breast Cancer PatientsReport as inadecuate

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This study investigated the relationships between background intestinal uptake on 18F–FDG PET and cardio-metabolic risk CMR factors.


A total of 326 female patients that underwent 18F–FDG PET to determine the initial stage of breast cancer were enrolled. None of the patients had history of diabetes or hypertension. The background intestinal uptake on PET was visually graded low vs. high uptake group and quantitatively measured using the maximal standardized uptake value SUVmax. SUVmax of 7 bowel segments duodenum, jejunum, ileum, cecum, hepatic flexure, splenic flexure, and descending colon-sigmoid junction were averaged for the total bowel TB SUVmax. Age, body mass index BMI, fasting blood glucose level BST, triglyceride TG, cholesterol, high density lipoprotein HDL, and low density lipoprotein LDL were the considered CMR factors. The relationships between background intestinal 18F–FDG uptake on PET and diverse CMR factors were analyzed.


The visual grades based on background intestinal 18F–FDG uptake classified 100 30.7% patients into the low uptake group, while 226 69.3% were classified into the high uptake group. Among CMR factors, age p = 0.004, BMI p<0.001, and TG p<0.001 were significantly different according to visual grade of background intestinal 18F–FDG uptake. Quantitative TB SUVmax showed significant positive correlation with age r = 0.203, p<0.001, BMI r = 0.373, p<0.001, TG r = 0.338, p<0.001, cholesterol r = 0.148, p = 0.008, and LDL r = 0.143, p = 0.024 and significant negative correlation with HDL r = -0.147, p = 0.022. Multivariate analysis indicated that BMI and TG were independent factors in both visually graded background intestinal 18F–FDG uptake p = 0.027 and p = 0.023, respectively and quantitatively measured TB SUVmax p = 0.006 and p = 0.004, respectively.


Increased background intestinal 18F–FDG uptake on PET may suggest alteration of lipid metabolism and risk of cardio-metabolic disease in non-diabetic and non-hypertensive breast cancer patients.

Author: Hai-Jeon Yoon, Han-Na Kim, Yeojun Yun, Yemi Kim, Ae-Na Ha, Hyung-Lae Kim , Bom Sahn Kim



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