Comparison of NK-1 Receptor Antagonist Maropitant to Morphine as a Pre-Anaesthetic Agent for Canine OvariohysterectomyReportar como inadecuado

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To compare the NK-1 receptor antagonist maropitant to morphine during and after surgery in dogs undergoing ovariohysterectomy OHE.


30 healthy female dogs were randomly divided to receive either a pre-anaesthetic dose of morphine 0.5 mg-kg SQ or maropitant 1 mg-kg, SQ prior to OHE. Anaesthesia was induced with propofol and maintained with isoflurane. Expired isoflurane concentration, heart rate HR, systolic arterial pressure SAP and respiratory rate were measured. Post-operative pain scores and appetite were evaluated during the recovery period. Rescue analgesia morphine 0.1 mg-kg IV was administered as needed post-operatively based on blinded pain score assessments.


Although clinically comparable; during surgical stimulation, the maropitant group had lower HR 108±18 vs 115±24 bpm; p = 0.04, lower SAP 114±23 vs 125±23 mmHg; p = 0.003 and required slightly lower percent of isoflurane anaesthetic 1.35±0.2 vs 1.51±0.4%; p = 0.005, when compared to the morphine group. In the recovery period, the maropitant group had lower pain scores at extubation 1.7±0.7 vs 3.4±2.3; p = 0.0001 and were more likely to eat within 3 hours after extubation 64.7 vs 15.3%. However, post-operative rescue analgesia requirements were similar between groups. All other measured parameters were similar between groups. The overall difference observed between groups was small and all monitored and measured parameters were within the expected range for anesthetized dogs.

Clinical Significance

No major differences in cardiorespiratory parameters or anaesthetic requirements were observed between maropitant and morphine when used as a pre-anesthetic agent for OHE. Further studies are necessary to fully elucidate the benefits of maropitant as a pre-anaesthetic agent for canine OHE.

Autor: Megan Marquez, Pedro Boscan , Heather Weir, Pamela Vogel, David C. Twedt



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