Evaluation in a Dog Model of Three Antimicrobial Glassy Coatings: Prevention of Bone Loss around Implants and Microbial AssessmentsReportar como inadecuado

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The aim of the present study is to evaluate, in a ligature-induced peri-implantitis model, the efficacy of three antimicrobial glassy coatings in the prevention of biofilm formation, intrasulcular bacterial growth and the resulting peri-implant bone loss.


Mandibular premolars were bilaterally extracted from five beagle dogs. Four dental implants were inserted on each hemiarch. Eight weeks after, one control zirconia abutment and three with different bactericidal coatings G1n-Ag, ZnO35, G3 were connected. After a plaque control period, bacterial accumulation was allowed and biofilm formation on abutments was observed by Scanning Electron Microscopy SEM. Peri-implantitis was induced by cotton ligatures. Microbial samples and peri-implant crestal bone levels of all implant sites were obtained before, during and after the breakdown period.


During experimental induce peri-implantitis: colony forming units counts from intrasulcular microbial samples at implants with G1n-Ag coated abutment remained close to the basal inoculum; G3 and ZnO35 coatings showed similar low counts; and anaerobic bacterias counts at control abutments exhibited a logarithmic increase by more than 2. Bone loss during passive breakdown period was no statistically significant. Additional bone loss occurred during ligature-induce breakdown: 0.71 SD 0.48 at G3 coating, 0.57 SD 0.36 at ZnO35 coating, 0.74 SD 0.47 at G1n-Ag coating, and 1.29 SD 0.45 at control abutments; and statistically significant differences p<0.001 were found. The lowest bone loss at the end of the experiment was exhibited by implants dressing G3 coated abutments mean 2.1; SD 0.42.


Antimicrobial glassy coatings could be a useful tool to ward off, diminish or delay peri-implantitis progression.

Autor: Roberto López-Píriz , Eva Solá-Linares, Mercedes Rodriguez-Portugal, Beatriz Malpica, Idoia Díaz-Güemes, Silvia Enciso, Leti

Fuente: http://plos.srce.hr/


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