Non-Invasive Evaluation of Hepatic Fibrosis: The Diagnostic Performance of Magnetic Resonance Elastography in Patients with Viral Hepatitis B or CReportar como inadecuado




Non-Invasive Evaluation of Hepatic Fibrosis: The Diagnostic Performance of Magnetic Resonance Elastography in Patients with Viral Hepatitis B or C - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Purpose

To compare the accuracy of magnetic resonance elastography MRE with that of aspartate aminotransferase-to-platelet ratio index APRI for estimating the stage of hepatic fibrosis in patients with chronic hepatitis B virus HBV or chronic hepatitis C virus HCV infection.

Materials and Methods

We retrospectively enrolled 160 patients with chronic hepatitis and 25 healthy living liver donors. Fibrosis stage METAVIR, F0 to F4 was determined histopathologically for all patients. APRI was recorded at the time of histopathologic examination and liver stiffness values were measured on MRE quantitative stiffness maps. The cutoff values, sensitivity, and specificity of MRE and APRI for each fibrosis stage were determined using receiver operating characteristic ROC analysis.

Results

MRE had a significantly greater area under the ROC curve than APRI score for discriminating among METAVIR stages F2-F4. Using a cutoff value of 2.80 kPa, MRE had a sensitivity of 94.4% and a specificity of 97.8% for detecting significant fibrosis ≥F2. There were no significant differences in fibrosis stage between patients with HBV and those with HCV infection. For ≥F2, the cutoffs were 2.47 kPa 100% sensitivity, 2.80 kP maximum sum of sensitivity and specificity, and 3.70 kPa 100% specificity.

Conclusions

MRE is a more accurate modality than APRI for detecting significant fibrosis in patients with chronic HBV or HCV infection. Antiviral treatment should be considered in patients with liver stiffness values ≥ 2.8 kPa.



Autor: Wen-Pei Wu, Chen-Te Chou , Ran-Chou Chen , Chih-Wei Lee, Kwo-Whei Lee, Hwa-Koon Wu

Fuente: http://plos.srce.hr/



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