Diagnostic Value of the Combination of Golgi Protein 73 and Alpha-Fetoprotein in Hepatocellular Carcinoma: A Meta-AnalysisReportar como inadecuado




Diagnostic Value of the Combination of Golgi Protein 73 and Alpha-Fetoprotein in Hepatocellular Carcinoma: A Meta-Analysis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Conflicting results have been widely reported on the use of Golgi protein 73 GP73 as a serum biomarker for diagnosing hepatocellular carcinoma HCC. This study evaluated the accuracy of GP73, alpha-fetoprotein AFP, and GP73 + AFP for diagnosing HCC. The meta-analysis was performed on 11 studies that were selected by means of a comprehensive systematic literature review. Summary diagnostic accuracy, meta-regression analysis for heterogeneity and publication bias, and other statistical analyses were performed using Meta-Disc version 1.4 and Stata version 12.0. Pooled sensitivity, specificity, and diagnostic odds ratio were 0.77 95% CI: 0.75–0.79, 0.91 95% CI: 0.90–0.92, and 12.49 95% CI: 4.91–31.79 for GP73; 0.62 95% CI: 0.60–0.64, 0.84 95% CI: 0.83–0.85, and 11.61 95% CI: 8.02–16.81 for AFP; and 0.87 95% CI: 0.85–0.89, 0.85 95% CI: 0.84–0.86, and 30.63 95% CI: 18.10–51.84 for GP73 + AFP. The area under the curve values were 0.86, 0.84, and 0.91 for GP73, AFP, and GP73 + AFP, respectively. These results indicate that for HCC diagnosis, the accuracy of GP73 was higher than that of AFP, and that GP73 + AFP exhibited significantly higher diagnostic accuracy than did GP73 or AFP alone.



Autor: Meiyu Dai , Xiaoli Chen , Xuexiang Liu, Zheng Peng, Jie Meng, Shengming Dai

Fuente: http://plos.srce.hr/



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