The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease PatientsReportar como inadecuado




The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease Patients - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background

Stunting, anemia and inflammation are frequently observed in children with end-stage renal disease ESRD.

Objectives

To assess anthropometric, hematological and inflammatory data and to study their potential interrelationship in Guatemalan juveniles undergoing hemodialysis HD and peritoneal dialysis PD.

Methods

54 juveniles 7–20 years of age were recruited in FUNDANIER, Guatemala City: 27 on HD and 27 PD. Hemoglobin, serum iron, transferrin, serum transferrin receptor sTfR, serum ferritin, transferrin saturation and iron-binding capacity, white blood cell count WBC, erythrocyte sedimentation rate ESR, C-reactive protein CRP, as well as IL-6, IL-1 and TNF-α, weight and height were determined by standard methods. Hepcidin–25 Hep-25 was assessed by weak cation exchange time-of-flight mass-spectrometry.

Results

92% and 55% of HD and PD children, respectively, were stunted and 95% and 85% were anemic. Among iron status biomarkers, serum ferritin was massively increased and significantly higher in the HD group compared to the PD group. Hep-25 was also greatly elevated in both groups. 41% of HD patients showed increments in three or more inflammatory biomarkers, while it was 2 or less in all PD subjects.

Conclusions

The degree of stunting, the prevalence and severity of anemia in Guatemalan juvenile ESRD far exceed the national statistics for this low-income Central American country. Ferritin and Hep-25 concentrations were elevated, with the latter to an extraordinary magnitude. Additional biomarkers of inflammation not directly related to iron status were elevated as well. The role of both disease- and environment-related factors in combination best explains the magnitude of the biomarker abnormalities.



Autor: Juliana Casimiro de Almeida, Randall Lou-Meda, Marion Olbert, Markus Seifert, Günter Weiss, Erwin T. Wiegerinck, Dorine W. Swink

Fuente: http://plos.srce.hr/



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