THE DYNAMICS OF HAEMOSTATIC PARAMETERS IN ACUTE PSYCHOTIC PATIENTS: A ONE-YEAR PROSPECTIVE STUDYReportar como inadecuado




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Psychiatria Danubina, Vol.25 No.2 June 2013. -

Background: The primary goal of the present study was to replicate our previous finding of increased coagulation and

thrombocytes activity in drug-naïve psychotic patients in comparison with healthy controls and ascertain whether the blood levels of

thrombogenesis markers further increase over the course of a consecutive one-year antipsychotic treatment.

Subjects and methods: We investigated the plasma levels of markers indicating activation of coagulation D-dimers and Factor

VIII and platelets soluble P-selectin, sP-selectin in an antipsychotic-naive group of nineteen men and seventeen women with acute

psychosis age 28.1±8.0 years, body mass index 22.6±4.2, and thirty-seven healthy volunteers matched for age, gender and body

mass index. In the patient group, we repeated these assessments after three months and again after one year of antipsychotic

treatment.

Results: D-dimers median 0.38 versus 0.19 mg-l; p=0.00008, factor VIII median 141.5% versus 110%; p=0.02 and sPselectin

median 183.6 versus 112.4 ng-ml; p=0.00005 plasma levels were significantly increased in the group of patients with acute

psychosis prior to treatment compared with healthy volunteers. The plasma levels of sP-selectin varied significantly p=0.016 in the

course of the one-year antipsychotic treatment, mainly between 3 and 6 months after start of therapy. The plasma levels of D-dimers

and factor VIII did not change significantly, D-dimers remained elevated in contrast to the healthy controls.

Conclusions: Patients with acute psychosis had increased levels of markers of thrombogenesis in comparison to the healthy

volunteers. The haemostatic parameters also remained elevated during the one-year antipsychotic treatment.

psychosis – thromboembolism - markers of thrombogenesis – coagulation - antipsychotic treatment



Autor: Jiří Masopust Masopust - ; Department of Psychiatry, Charles University in Prague, Faculty of Medicine in Hradec Králové, and

Fuente: http://hrcak.srce.hr/



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