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Current Gerontology and Geriatrics ResearchVolume 2008 2008, Article ID 848267, 7 pages

Review Article

Department of Internal Medicine, Diabetes, and Metabolic Diseases, University Hospital of Strasbourg, 67091 Strasbourg, France

Department of Internal Medicine and Geriatrics, University Hospital of Strasbourg, 67091 Strasbourg, France

Laboratoire d'Immunogénétique-Allergologie, Centre de Recherche Public de la Santé CRP-Santé de Luxembourg, 1526 Luxembourg, Luxembourg

Received 3 February 2008; Accepted 18 April 2008

Academic Editor: Irene Rea

Copyright © 2008 Emmanuel Andrès et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cobalamin vitamin B12 deficiency is particularly common in the elderly >65 years of age but is often unrecognized because its clinical manifestations are subtle; however, they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. In the elderly, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorption. Food-cobalamin malabsorption syndrome is a disorder characterized by the inability to release cobalamin from food or its binding proteins. This syndrome is usually caused by atrophic gastritis, related or unrelated to Helicobacter pylori infection, and long-term ingestion of antacids and biguanides. Management of cobalamin deficiency with cobalamin injections is currently well documented but new routes of cobalamin administration oral and nasal are being studied, especially oral cobalamin therapy for food-cobalamin malabsorption.

Autor: Emmanuel Andrès, Thomas Vogel, Laure Federici, Jacques Zimmer, Ecaterina Ciobanu, and Georges Kaltenbach



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